

Previous studies from our laboratory have shown a role of ecto-5’-NT in glioma progression and tissue invasiveness events.

In breast cancer, the involvement of ecto-5’-NT in invasiveness and its interaction with extracellular matrix proteins were demonstrated. Sadej and co-workers (2006) demonstrated that ecto-5’-NT expression increased with the degree of malignancy of human melanoma cell lines, where higher expression levels were measured in a metastatic melanoma cell line. Ecto-5’-NT influences cancer progression in different types of tumors, including bladder and breast cancer, melanomas and gliomas. Adenosine activates P1 metabotropic receptors, subdivided into A 1, A 2A, A 2B and A 3 receptors, which participate in the control of intracellular cAMP levels. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Įcto-5’-nucleotidase/CD73 (ecto-5’-NT) is expressed by various human tissues and considered the main producer of extracellular adenosine. 303016/2009-4) and Fundo de Incentivo a Pesquisa e Eventos - FIPE/HCPA (Proc. 2012/50880-4) Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq (Proc. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP (Proc.

Received: JAccepted: OctoPublished: October 22, 2015Ĭopyright: © 2015 Cappellari et al. (2015) Ecto-5’-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model. Citation: Cappellari AR, Pillat MM, Souza HDN, Dietrich F, Oliveira FH, Figueiró F, et al.
